The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The Buffalo Bills are heading out of the their bye and are set to face the San Francisco 49ers in Week 13 on “Sunday Night ...

There is a high Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the 49ers (5-6) and the ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

The highly anticipated Buffalo Bills clash against the San Francisco 49ers, scheduled for Sunday at Highmark Stadium, faces ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...