San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

There is a high Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the 49ers (5-6) and the ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

The Bills will take on the San Francisco 49ers on Sunday night at Highmark Stadium in Orchard Park. Lake-effect snow bands ...

Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the 49ers +6.5 (+100). This betting advice is ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

Buffalo (9-2) will return to action on Sunday night when they host the San Francisco 49ers (5-6). The Bills are perfect ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

The highly anticipated Buffalo Bills clash against the San Francisco 49ers, scheduled for Sunday at Highmark Stadium, faces ...